2016

9993 bookmarks
Newest
Real-World Clinical Experience With Idebenone in the Treatme... Journal of Neuro-Ophthalmology
Real-World Clinical Experience With Idebenone in the Treatme... Journal of Neuro-Ophthalmology
Methods: Open-label, multicenter, retrospective, noncontrolled analysis of long-term visual acuity and safety in 111 LHON patients treated with idebenone (900 mg/day) in an expanded access program. Eligible patients had a confirmed mitochondrial DNA mutation and had experienced the onset of symptoms (most recent eye) within 1 year before enrollment. Data on visual acuity and adverse events were collected as per normal clinical practice. Efficacy was assessed as the proportion of patients with either a clinically relevant recovery (CRR) or a clinically relevant stabilization (CRS) of visual acuity. In the case of CRR, time to and magnitude of recovery over the course of time were also assessed. Results: At time of analysis, 87 patients had provided longitudinal efficacy data. Average treatment duration was 25.6 months. CRR was observed in 46.0% of patients. Analysis of treatment effect by duration showed that the proportion of patients with recovery and the magnitude of recovery increased with treatment duration. Average gain in best-corrected visual acuity for responders was 0.72 logarithm of the minimal angle of resolution (logMAR), equivalent to more than 7 lines on the Early Treatment Diabetic Retinopathy Study (ETDRS) chart. Furthermore, 50% of patients who had a visual acuity below 1.0 logMAR in at least one eye at initiation of treatment successfully maintained their vision below this threshold by last observation. Idebenone was well tolerated, with most adverse events classified as minor. Conclusions: These data demonstrate the benefit of idebenone treatment in recovering lost vision and maintaining good residual vision in a real-world setting. Together, these findings indicate that idebenone treatment should be initiated early and be maintained more than 24 months to maximize efficacy. Safety results were consistent with the known safety profile of idebenone....
·journals.lww.com·
Real-World Clinical Experience With Idebenone in the Treatme... Journal of Neuro-Ophthalmology
Magnesium for neuroprotection in ischaemic stroke rationale for use and evidence of effectiveness - PubMed
Magnesium for neuroprotection in ischaemic stroke rationale for use and evidence of effectiveness - PubMed
Magnesium exhibits a range of neuronal and vascular actions that may ameliorate ischaemic CNS insults, including stroke. Significant neuroprotection with magnesium has been observed in different models of focal cerebral ischaemia in many laboratories, with infarct volume reductions between 25 and 61 …
·pubmed.ncbi.nlm.nih.gov·
Magnesium for neuroprotection in ischaemic stroke rationale for use and evidence of effectiveness - PubMed
Epidemic Of Heart Disease Caused By COVID Vaccines And Related Stress
Epidemic Of Heart Disease Caused By COVID Vaccines And Related Stress
Pandemic, epidemic, or a medical emergency. No matter what we call it, people suffering from vascular disease have dramatically increased, and too many are dying from it. Not only is there no vaccine possible for heart disease, but in all probability, the COVID vaccines are driving the pain, suffering, and death through sudden onset heart... View Article
·drsircus.com·
Epidemic Of Heart Disease Caused By COVID Vaccines And Related Stress
National Journal of Physiology, Pharmacy and Pharmacology
National Journal of Physiology, Pharmacy and Pharmacology
Background: Rheumatoid arthritis is a chronic inflammatory disease of autoimmune etiology. Current treatment includes non-steroidal anti-inflammatory drugs, selective cyclooxygenase-2 inhibitors, glucocorticoids, and disease-modifying antirheumatoid drugs, newer agents such as tumor necrosis factor-α inhibitors, and monoclonal antibodies have adverse effects such as peptic ulcer, renal toxicity, and hematological toxicity. Moreover, they are expensive when used on a long-term basis. Hence, it is necessary to find out the new cost effective as well as less toxic drug as alternative. Aim and Objective: The present study was taken up to evaluate antiarthritic activity of Aloe vera aqueous extract (AVE) in Wistar albino rats when used orally. Materials and Methods: A total 36 no. of healthy Wistar albino rats of weight 100–200 mg were used and divided into six different groups containing six rats in each. Into subplantar region of hind paw of all rats except normal control, 0.1 mL of complete Freund’s adjuvant (6 mg Mycobacterium butyricum suspended in heavy paraffin oil) was injected for induction of arthritis. The rats were treated with vehicle (gum acacia), standard drugs (indomethacin and dexamethasone) and test drug, that is, AVE 125 mg/kg, 250 mg/kg for 12 days. The rats were evaluated by measuring the % increase in paw edema volume and paw thickness (joint diameter), assessing the biophysical parameters (arthritic score), hematological parameters erythrocyte sedimentation rate, rheumatoid factor, and histopathological study of joints (arthritic index) for testing the antiarthritic potential. Results: AVE 250 mg/kg showed significant antiarthritic property as that of standard indomethacin and dexamethasone in terms of reduction in inflammation and arthritic scores. Conclusion: AVE at 250 mg/kg offered significant protection against arthritis and inflammation and can be a safer alternative for long term use.
·njppp.com·
National Journal of Physiology, Pharmacy and Pharmacology
Covid Care - Healthcare Redefined-An Innovative Approach to Health Care
Covid Care - Healthcare Redefined-An Innovative Approach to Health Care
Covid Care At Synergy Health DPC, our goal is to keep you healthy at home Should you or any of your family seek to prevent becoming ill with Covid, experience the common symptoms of Covid or have lingering effects of Post Covid Syndrome, please be assured that we offer several different Covid protocol options that… Continue reading Covid Care
·synergyhealthdpc.com·
Covid Care - Healthcare Redefined-An Innovative Approach to Health Care
Healthcare Redefined-An Innovative Approach to Health Care
Healthcare Redefined-An Innovative Approach to Health Care
We provide affordable concierge TeleHealth visits to all of our patients ages 12 and up. Our providers often can schedule an acute care visit with limited wait times. We also offer specialized services to address dementia, fibromyalgia and other long term conditions. Additionally, we are available as a health advocate should you or a loved one need hospital or specialist care
·synergyhealthdpc.com·
Healthcare Redefined-An Innovative Approach to Health Care
DR. PAULS FIGHT - Home
DR. PAULS FIGHT - Home
Checks  can be mailed to: Dr Paul's Fight c/o: Paul Thomas  11790 SW Barnes Rd. Suite 140 Portland Or 97225 Write DrPaulsFight in memo or on a piece of paper
·drpaulsfight.com·
DR. PAULS FIGHT - Home
Beyond Terrible - An Age of Mayhem, Madness, and Monsters
Beyond Terrible - An Age of Mayhem, Madness, and Monsters
I should have titled this essay the worst story ever told, so fasten your seatbelts because things will only worsen from here. I am afraid that there will be little to no good news from this point forward. Evil is conquering the world, and they have us exactly where they want us. There are no... View Article
·drsircus.com·
Beyond Terrible - An Age of Mayhem, Madness, and Monsters
In Love with CO2 and Bicarbonates
In Love with CO2 and Bicarbonates
Our life and health depend on having enough CO2 in the blood and tissues. Carbon dioxide is both an essential a nutrient and a product of respiration. Its lack or deficiency is a starting point for disturbances in the body up to and including cancer. The last thing a person wants is to be bicarbonate... View Article
·drsircus.com·
In Love with CO2 and Bicarbonates
Network Pharmacology-Based Study on the Mechanism of Aloe Vera for Treating Cancer
Network Pharmacology-Based Study on the Mechanism of Aloe Vera for Treating Cancer
Background. Aloe vera has long been considered an anticancer herb in different parts of the world. Objective. To explore the potential mechanism of aloe vera in the treatment of cancer using network pharmacology and molecule docking approaches. Methods. The active ingredients and corresponding protein targets of aloe vera were identified from the TCMSP database. Targets related to cancer were obtained from GeneCards and OMIM databases. The anticancer targets of aloe vera were obtained by intersecting the drug targets with the disease targets, and the process was presented in the form of a Venn plot. These targets were uploaded to the String database for protein-protein interaction (PPI) analysis, and the result was visualized by Cytoscape software. Go and KEGG enrichment were used to analyze the biological process of the target proteins. Molecular docking was used to verify the relationship between the active ingredients of aloe vera and predicted targets. Results. By screening and analyzing, 8 active ingredients and 174 anticancer targets of aloe vera were obtained. The active ingredient-anticancer target network constructed by Cytoscape software indicated that quercetin, arachidonic acid, aloe-emodin, and beta-carotene, which have more than 4 gene targets, may play crucial roles. In the PPI network, AKT1, TP53, and VEGFA have the top 3 highest values. The anticancer targets of aloe vera were mainly involved in pathways in cancer, prostate cancer, bladder cancer, pancreatic cancer, and non-small-cell lung cancer and the TNF signaling pathway. The results of molecular docking suggested that the binding ability between TP53 and quercetin was the strongest. Conclusion. This study revealed the active ingredients of aloe vera and the potential mechanism underlying its anticancer effect based on network pharmacology and provided ideas for further research.
·hindawi.com·
Network Pharmacology-Based Study on the Mechanism of Aloe Vera for Treating Cancer