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Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
There are limited proven therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This literature review focuses on vitamin C deficiency in respiratory infections, including COVID-19, and the mechanisms of action in infectious disease, including support of the stress response, its role in preventing and treating colds and pneumonia, and its role in treating sepsis and COVID-19. The evidence to date indicates that oral vitamin C (2–8 g/day) may reduce the incidence and duration of respiratory infections and intravenous vitamin C (6–24 g/day) has been shown to reduce mortality, intensive care unit (ICU) and hospital stays, and time on mechanical ventilation for severe respiratory infections. Further trials are urgently warranted. Given the favourable safety profile and low cost of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it may be worthwhile testing patients’ vitamin C status and treating them accordingly with intravenous administration within ICUs and oral administration in hospitalised persons with COVID-19.
·mdpi.com·
Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
Long-term persistence of the SARS-CoV-2 spike protein: evidence and implications
Long-term persistence of the SARS-CoV-2 spike protein: evidence and implications
This paper discusses the recent study by Bansal et al. on the detection of spike protein in persons vaccinated with the Pfizer mRNA vaccine. The most significant finding is that spike protein is found on exosomes, that is, cell-derived vesicles, for at least four months after the second injection. This surprisingly long persistence raises the prospect of sustained inflammation within and damage to organs which
·doctors4covidethics.org·
Long-term persistence of the SARS-CoV-2 spike protein: evidence and implications
Long Term Covid - What You Need to Know Today
Long Term Covid - What You Need to Know Today
Dr. Carlos del Rio joins us today to discuss these long-term health consequences of COVID-19 in terms of frequency, mechanisms, and possible therapeutics.
·drperlmutter.com·
Long Term Covid - What You Need to Know Today
Spike Proteins In Immune Cells - Dr. Bruce Patterson Discusses COVID Long Haul
Spike Proteins In Immune Cells - Dr. Bruce Patterson Discusses COVID Long Haul
Spike Proteins In Immune Cells - Dr. Bruce Patterson Discusses COVID Long Haul Dr. Bruce Patterson’s team has discovered that the S1 pieces of the spike proteins persist in the monocytes resulting in immune dysregulation and long-haul syndrome. Let’s discuss these findings with him. Dr. Patterson’s site: https://covidlonghaulers.com/ Disclosure: Dr. Mobeen Syed, or DrBeen have no commercial interest with Dr. Bruce Patterson’s organization. Want to support this work to get a balanced take on the medical sciences? Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US Join us on Discord: https://discord.gg/bkmg3rk3sQ Claim your #koolbeen title here: https://www.drbeen.com/koolbeen-title-registry/ #drbeen #koolbeens #COVID
·facebook.com·
Spike Proteins In Immune Cells - Dr. Bruce Patterson Discusses COVID Long Haul
DR. PAUL THOMAS MD - DrPaulApproved
DR. PAUL THOMAS MD - DrPaulApproved
DrPaulApproved.com & Dr. Paul Thomas MD, brings you the best, and most important research, information, products, blogs and videos, vitamins and nutritional supplements, and provide links to information we feel you should not go without.
·paulthomasmd.com·
DR. PAUL THOMAS MD - DrPaulApproved
Life Free Full-Text Trehalose Activates Hepatic and Myocardial Autophagy and Has Anti-Inflammatory Effects in dbdb Diabetic Mice
Life Free Full-Text Trehalose Activates Hepatic and Myocardial Autophagy and Has Anti-Inflammatory Effects in dbdb Diabetic Mice
Db/db mice (carrying a mutation in the gene encoding leptin receptor) show autophagy suppression. Our aim was to evaluate the effect of autophagy inducer trehalose on liver and heart autophagy in db/db mice and to study inflammation dysregulation and the suitability of chitinases’ expression levels as diabetes markers. Thirty-eight male db/db mice and C57/BL mice (control) were used. The db/db model manifested inflammation symptoms: overexpression of TNF-α in the spleen and underexpression of IL-10 in the liver and spleen (cytokine imbalance). Simultaneously, we revealed decreased expression of chitotriosidase (CHIT1) and acid mammalian chitinase (CHIA) in the liver of db/db mice. CHIA expression in db/db mice is significantly lower only in the spleen. Trehalose treatment significantly reduced blood glucose concentration and glycated hemoglobin. Treatment of db/db mice by trehalose was followed by increased autophagy induction in the heart and liver (increased autolysosomes volume density studied by morphometric electron-microscopic method). Trehalose exerted beneficial cardiac effects possibly via increased lipophagy (uptake of lipid droplets). The autophagy activation by trehalose had several positive effects on the heart and liver of db/db mice; therefore, lipophagy activation seems to be a promising therapy for diabetes.
·mdpi.com·
Life Free Full-Text Trehalose Activates Hepatic and Myocardial Autophagy and Has Anti-Inflammatory Effects in dbdb Diabetic Mice
Predicting & Preventing Long-Haul Covid - with Dr. Heath & Dr. Su The Empowering Neurologist EP146 - YouTube
Predicting & Preventing Long-Haul Covid - with Dr. Heath & Dr. Su The Empowering Neurologist EP146 - YouTube
As it relates to COVID-19, there seems to be an incredible amount of interest in the death rate which happens to be exceedingly, exceedingly low. Why I find this challenging is because there is another problem associated with this infection that isn't getting the type of attention that it deserves. This goes by the common name, long-haul Covid. This simply means that after "recovering" from the initial infection, a fairly significant percentage of individuals continue to experience symptoms that at times may be debilitating. Research just published has demonstrated an ability to actually predict who is at the greatest risk for developing long-term symptoms after COVID-19 infection. We will be interviewing today Dr. James Heath and Dr. Yapeng Su from the Institute for Systems Biology at the University of Washington. They have identified four characteristics that are clearly and strongly associated with persistent symptoms of Covid-19 and as such, this is important information for all of us. They include: The presence of particular autoantibodies A high viral (RNA) load Type 2 diabetes Reactivation of the Epstein-Barr virus, which sits latent in the blood of most people following a childhood infection I’ll tell you more about these dedicated researchers in the intro to the video. ==== TIMESTAMPS: 0:00 Intro 3:40 Important Study on Longterm Effects 7:11 Predicting Severity of Disease 15:00 4 Ways to Predict 21:30 Chronic EBV 26:00 Preventing Long-Haul Covid 39:08 Conclusion ==== James R. Heath, PhD President and Professor, Institute for Systems Biology Professor of Bioengineering, Univ of Washington James Heath serves as the President of the Institute for Systems Biology in Seattle WA. Until early 2018 he was the Elizabeth W. Gilloon Professor of Chemistry at Caltech. For 15 years he directed the National Cancer Institute funded NSB Cancer Center program. Dr. Heath received a BSc in 1984 from Baylor University and a PhD in chemistry in 1988 from Rice University, where he was the principal student involved in the Nobel Prize–winning discovery of C60 and the fullerenes. He was a Miller Fellow at UC Berkeley from 1988 to 1991 and served on the technical staff at IBM Watson Labs from 1991 to 1993. In 1994 he joined the faculty at UCLA. He founded the California NanoSystems Institute in 2000 and served as its director until moving to Caltech. Dr. Heath’s lab works on fundamental problems at the interface of the chemical, physical, biological, and biomedical sciences, with focus areas of molecular biotechnologies and oncology. Dr. Heath has published around 400 refereed scientific publications with an h-index of 122. He has received numerous awards, including a Public Service Commendation from California Governor Grey Davis, the Director’s Service Award from the NCI, the Sackler Prize, Irving Weinstein Award from the AACR, and he was named by Forbes in 2011 as one of the 7 most powerful innovators in the world.. He has founded several companies, including Integrated Diagnostics (sold to Biodesix in 2018), Indi Molecular, PACT Pharma, Sofie Biosciences, ISB BioAnalytica, and Isoplexis (now a public company). _______ Dr. Yapeng Su received his Ph.D. degree at Caltech, co-advised by Prof. James R. Heath and Prof. David Baltimore. Yapeng’s Ph.D. research resided at the intersection of physical science, biotechnology, and systems biology with a particular focus on cancer. His research utilized systems biology approaches and various single-cell technologies to tackle one of the biggest problems in cancer: drug resistance. His Ph.D. thesis was awarded the highest honor of the Division of Chemistry and Chemical Engineering at Caltech. After obtaining his Ph.D., Yapeng conducted a brief postdoc research scientist in Prof. Leroy Hood's lab at the Institute for Systems Biology. In close collaboration with a group of world-leading immunologists (Prof. Mark M. Davis, Prof. Phil Greenberg, Prof. Raphael Gottardo, Prof. James R Heath, Prof. Jeff Bluestone, Prof. Lewis Lanier, Prof. Alan Aderem), Yapeng’s research in the Hood lab utilizes data science, multi-omic bulk, and single-cell analysis to investigate the systems immunology of COVID-19. Currently, Yapeng is a Mahan Fellow at the Fred Hutch Cancer Research Center. His research utilized systems-level big data and machine learning to provide rationales on how to better engineer live immune cells as an effective therapy for treating cancer. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1
·youtube.com·
Predicting & Preventing Long-Haul Covid - with Dr. Heath & Dr. Su The Empowering Neurologist EP146 - YouTube
Pathologist on Ryan Cole on the mystery blood clots
Pathologist on Ryan Cole on the mystery blood clots
He thinks they are due to the vaccine. He couldn't think of any other cause. He only started hearing lots of reports of this in Jan 2022. So it couldn't be caused by COVID. So if it wasn't the vaccine
·rumble.com·
Pathologist on Ryan Cole on the mystery blood clots
How Long Does It Take For Gluten To Leave Your System - YouTube
How Long Does It Take For Gluten To Leave Your System - YouTube
Gluten Shield - specially formulated for those seeking a gluten free lifestyle: glutenfreesociety.org/GlutenShield Tonight we're going to be answering that frequently asked question "once you get glutened, how long does it take for that damage to leave your system? How long does it take to recover?" It's a very common question that we get so we're going to be diving into the answers and also strategies and how you can deal with it, how you can overcome it, and strategies on how to understand and recognize where better to to identify gluten and hidden gluten. So stick with me all the way through the end, because you're not going to want to miss overcoming how to get glutened and and the timing sequence that it takes...so let's dive in!
·youtube.com·
How Long Does It Take For Gluten To Leave Your System - YouTube
Aloe vera and Streptozotocin-Induced Diabetes Mellitus SpringerLink
Aloe vera and Streptozotocin-Induced Diabetes Mellitus SpringerLink
Revista Brasileira de Farmacognosia - Diabetes mellitus is defined as prolonged hyperglycemia, which can harm the eyes, kidneys, and cardiovascular and neurological systems. Herbal agents and their...
·link.springer.com·
Aloe vera and Streptozotocin-Induced Diabetes Mellitus SpringerLink
Understanding Type 1 Diabetes - YouTube
Understanding Type 1 Diabetes - YouTube
Employees of Hospitals, Schools, Universities and Libraries may download FREE medical animations from Nucleus by signing up for a free trial: http://nmal.nucleusmedicalmedia.com/free-trial-membership-a #Type1Diabetes #insulin #BloodSugar MEDICAL ANIMATION TRANSCRIPT: You or someone may have been diagnosed with type 1 diabetes. This video will help you understand what it is and why it's important to keep it under control. Type 1 diabetes is a condition where your pancreas makes little or no insulin. Insulin is a chemical your body needs to keep your blood sugar at a normal level. Carbohydrates are substances your body uses to make energy. After you eat food that contains carbohydrates, it eventually goes to your small intestine. In your small intestine, the food is broken down into single sugar molecules called glucose. The cells in your small intestine soak up the sugars, which pass into your bloodstream. When the blood reaches your pancreas, it detects the high amount of sugar in your blood. Normally, this causes your pancreas to put a chemical called insulin into your bloodstream. The insulin reduces the amount of sugar in your blood to a healthy level. How does insulin do this? As the blood moves through your body, the insulin and sugar exit the bloodstream into your tissues to reach your cells. Most cells have structures on their surfaces called insulin receptors. When insulin flows by, it attaches to the receptor. The insulin acts like a key in a lock to open up the cell so the sugar can get inside. Now your cell can use the sugar to make the energy it needs to work properly, and your blood sugar level drops back to its normal range. If you have type 1 diabetes, your pancreas loses its ability to make enough or any insulin. This can result in high blood sugar levels and other complications. In type 1 diabetes, your immune system attacks some cells in your pancreas by mistake. As a result, your pancreas makes little or no insulin. Without insulin, sugar cannot get into your cells. Without sugar, your cells don't have energy. And since the sugar is locked out of your cells, it builds up to a high level in your bloodstream. This is a condition called hyperglycemia, which can lead to serious complications. If you have questions about type 1 diabetes or any medications you have been prescribed, speak with your doctor. It is important to take your medications as directed by your doctor. Tell him or her about any side effects you have. ANH16174
·youtube.com·
Understanding Type 1 Diabetes - YouTube
A Mini-Review Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel Handayani Indonesian Journal of Cancer Chemoprevention
A Mini-Review Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel Handayani Indonesian Journal of Cancer Chemoprevention
Protective agent for hepatotoxicity is still a great challenge in the management of liver diseases. Aloe vera is a beneficial plant that has been studied for food supplements, cosmetic and herbal medicine. Aloe vera contains many compounds which have a role in body health including polysaccharides, phenolic, flavonoid, terpenoid, amino acid, and several minerals. There have been compelling evidences that natural phytochemicals and their derivatives have hepatoprotective activities. Information of the aloe vera and its mechanism of action for possible hepatoprotective activities, including in silico, in vitro, and in vivo studies were obtained from Pubmed, Science Direct, Scopus, and Google scholar search engines. This current review was focusing on the possible contribution of compounds inside aloe vera gel and the suggestion of its mechanism on protective effect, especially for liver. The complexity of monosaccharides composition, backbone structures, acetyl group, and molecular weight of aloe polysaccharides have possible correlations with its hepatoprotective effect. Most of the hepatoprotective mechanisms of aloe compounds are related to their protective effect against inflammation and oxidative stress. Several compounds may have combination effects or several targets lead to synergistic effects. Keywords: Aloe vera, food supplement, hepatoprotective, liver disease, mechanism of action.
·ijcc.chemoprev.org·
A Mini-Review Possible Mechanisms of Hepatoprotective Effect of Aloe Vera Gel Handayani Indonesian Journal of Cancer Chemoprevention
Oil Boycott is Part of the Globalist Plan for the Great Reset - YouTube
Oil Boycott is Part of the Globalist Plan for the Great Reset - YouTube
Are the Russian sanctions including the oil boycott truly the worst thing ever done to the USA economy? It is just a couple of dollars more per gallon right? Or is is there significantly more to it? Watch this episode of Last Days Breaking News with Nelson Walters to discover how this is part of a globalist plan for the Great Reset and what you should be watching for next. Also watch "Has Gog of Magog Already Begun? Is Putin Gog of Magog?" https://youtu.be/RY-vN-YOXiM
·youtube.com·
Oil Boycott is Part of the Globalist Plan for the Great Reset - YouTube